SAM Regulation of RyR2

Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure.

As a critical step toward understanding the role of abnormal intracellular Ca(2+) release via the ryanodine receptor (RyR(2)) during the development of hypertension-induced cardiac hypertrophy and heart failure, this study examines two questions: 1) At what stage, if ever, in the development of hypertrophy and heart failure is RyR(2) hyperphosphorylated at Ser(2808)? 2) Does the spatial distrib...

Regulation and dysregulation of cardiac ryanodine receptor (RyR2) open probability during diastole in health and disease

Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform

BACKGROUND AND PURPOSE Statins are amongst the most widely prescribed drugs for those at risk of cardiovascular disease, lowering cholesterol levels by inhibiting 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase. Although effective at preventing cardiovascular disease, statin use is associated with muscle weakness, myopathies and, occasionally, fatal rhabdomyolysis. As simvastatin, a commonly pre...

Sam Wang

Sam Wang is a pioneer in using statistical methods to analyze U.S. presidential election polls. In this election season interview with Neuron, he discusses diagnosing partisan gerrymandering, his research on the cerebellum, and how he analyzes polls with high accuracy.

Sam Reid

Pascal’s mechanical calculator and Babbage’s Analytic Engine set the stage for a great deal of modern computing machinery. Modern versions of these concepts were finally realized in von Neumann’s architecture in about 1950. However, the science of computing does not depend on physical implementations of these ideas, but rather on virtual machines—that is, abstractions that perform computations ...